Smouldering MS is characterised by the presence of smouldering lesions, a specific type of lesion observed in people living with MS that is chronically active and grows slowly over many years. You may also see them referred to as ‘rim lesions’, ‘chronic active lesions’ or ‘slowly expanding lesions’, alternative names used by scientists studying this particular area of MS disease.
Smouldering lesions are common in people living with MS and can affect anyone, regardless of the type of MS someone has or whether someone has a history of taking a disease modifying therapy (DMT). However, they are generally associated with progressive, and more aggressive and damaging forms of MS
Smouldering lesions differ from the normal lesions associated with MS, both in terms of appearance and behaviour.
Non-smouldering lesions have the ability to shrink or even to completely heal and disappear over time. This is in stark contrast to the behaviour of smouldering lesions which are thought to represent long-term, active inflammation in MS that is continuous in nature. These lesions instead remain and actively expand for many years.
A team of researchers have recently developed an imaging technique which makes it possible to visualise smouldering lesions and distinguish them from lesions that don’t smoulder based on their appearance – something that wasn’t previously possible. Using this advanced imaging technology, a distinctive, dark rim can be observed around smouldering lesions.
This rim is a visual characteristic that differentiates these lesions from others and is caused by microglia, a type of immune cell that roams the central nervous system (CNS) to remove any cell fragments, waste, and foreign material, such as bacteria and viruses. This is also why smouldering lesions are sometimes called ‘rim lesions’. Microglial activity in the CNS is normal and healthy, but that microglia can sometimes be triggered into an overactive state and that this is when they can cause disease.
We must clarify that smouldering lesions is still a relatively new topic and the role they play in MS is not fully understood, with further research required for us to realise the exact significance of this particular type of MS activity for people living with the condition.
However, a recent study of 192 people living with MS found that those with smouldering lesions were more likely to develop cognitive and mobility problems at an earlier age and had a lower brain volume when compared to people without any smouldering lesions. The study also concluded that people presenting with smouldering lesions were more likely to have MS that had become progressive.